Transient global amnesia-like episode due to mistaken intake of zolpidem: drug safety concern in the elderly

J Patient Saf. 2009 Mar;5(1):32-4. doi: 10.1097/PTS.0b013e3181990d62.

Abstract

Objective: Chronic insomnia is a common phenomenon among the elderly. Inaccurate handling and use of hypnotics in the elderly has become an important issue in patient safety. Older people who self-medicate often have a high risk for medication errors.

Methods and results: We described here the case of a 65-year-old woman who experienced recurrent transient anterograde amnesia, anxiety, bewilderment, and repetitive questioning that lasted for 2 to 3 hours after erroneously taking zolpidem. This mistake was due to the similarity in appearance between zolpidem and her newly prescribed anticholesterol drug, ezetimibe.

Conclusions: History of medication, particularly as regards hypnotics, should be carefully reviewed when a patient presents with transient global amnesia-like symptoms. The inadvertent use of drugs may be an underrecognized phenomenon among the elderly who self-medicate. When prescribing a new drug to elderly patients, especially hypnotics, physicians and pharmacists should educate them and their families about the proper use of these medications for their own safety.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Amnesia, Transient Global / chemically induced*
  • Drug-Related Side Effects and Adverse Reactions*
  • Female
  • Humans
  • Hypnotics and Sedatives / administration & dosage
  • Hypnotics and Sedatives / adverse effects*
  • Medication Errors / adverse effects*
  • Pyridines / administration & dosage
  • Pyridines / adverse effects*
  • Self Medication / adverse effects*
  • Zolpidem

Substances

  • Hypnotics and Sedatives
  • Pyridines
  • Zolpidem