Abstract
The poor and/or erratic oral bioavailability of polyphenolics can be improved using the PHYTOSOME delivery system, a strategy that enhances the rate and the extent of solubilization into aqueous intestinal fluids and the capacity to cross biomembranes. Phospholipids show affinity for polyphenolics, and form supramolecular adducts having a definite stoichiometry. This article reviews the preparation and characterization of PHYTOSOME complexes and their activity in various medicinal (cardiovascular, anti-inflammatory, hepatoprotective, anticancer) and cosmetic (skin aging) realms of application.
Copyright 2009 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Biological Availability
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Biological Transport
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Cardiovascular Diseases / drug therapy
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Cosmetics
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Flavonoids / chemistry
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Flavonoids / pharmacokinetics*
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Flavonoids / therapeutic use
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Humans
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Inflammation / drug therapy
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Intestines
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Liposomes / chemical synthesis*
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Liver Diseases / drug therapy
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Neoplasms / drug therapy
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Phenols / chemistry
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Phenols / pharmacokinetics*
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Phenols / therapeutic use
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Phospholipids* / chemistry
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Phytotherapy / methods*
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Plant Extracts / pharmacokinetics*
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Plant Extracts / therapeutic use
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Polyphenols
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Solubility
Substances
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Cosmetics
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Flavonoids
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Liposomes
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Phenols
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Phospholipids
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Plant Extracts
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Polyphenols