How aging compromises antiviral defenses: a role for imbalanced innate cytokine production

Rachel Guiton; Marc Dalod

doi:10.1016/j.chom.2009.10.008

How aging compromises antiviral defenses: a role for imbalanced innate cytokine production

Cell Host Microbe. 2009 Nov 19;6(5):397-9. doi: 10.1016/j.chom.2009.10.008.

Authors

Rachel Guiton¹, Marc Dalod

Affiliation

¹ Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, 13288 Marseille, France. guiton@ciml.univ-mrs.fr

PMID: 19917493
DOI: 10.1016/j.chom.2009.10.008

Abstract

Aging causes enhanced susceptibility to viral infections. Stout-Delgado et al. (2009) report increased IL-17A production but reduced type I interferon levels in old mice infected by herpes viruses. This imbalance between proinflammatory and antiviral innate cytokine responses causes immunopathology and compromises virus control, which together lead to death by liver failure.

Publication types

Comment
Research Support, Non-U.S. Gov't