New oligo-beta-(1,3)-glucan derivatives as immunostimulating agents

Karine Descroix; Vaclav Vetvicka; Isabelle Laurent; Frank Jamois; Jean-Claude Yvin; Vincent Ferrières

doi:10.1016/j.bmc.2009.10.053

New oligo-beta-(1,3)-glucan derivatives as immunostimulating agents

Bioorg Med Chem. 2010 Jan 1;18(1):348-57. doi: 10.1016/j.bmc.2009.10.053. Epub 2009 Oct 30.

Authors

Karine Descroix¹, Vaclav Vetvicka, Isabelle Laurent, Frank Jamois, Jean-Claude Yvin, Vincent Ferrières

Affiliation

¹ Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, Avenue du Général Leclerc, CS 50837, 35708 Rennes Cedex 7, France.

PMID: 19914838
DOI: 10.1016/j.bmc.2009.10.053

Abstract

Oligo-beta-(1,3)-glucans were chemically modified in order to introduce a structural variation specifically on the reducing end of the oligomers. The impact of well defined structural modulations was further studied on cancer cells and murin models to evaluate their cytotoxicity and immunostimulating potential.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adjuvants, Immunologic / chemistry*
Adjuvants, Immunologic / pharmacology*
Animals
Carbohydrate Conformation
Cell Line, Tumor
Female
Humans
Interleukin-2 / immunology
Mannose / chemistry*
Mannose / pharmacology*
Mice
Mice, Inbred BALB C
Phagocytosis / drug effects
beta-Glucans / chemistry*
beta-Glucans / pharmacology*

Substances

Adjuvants, Immunologic
Interleukin-2
beta-Glucans
Mannose