A new cytotoxic flavonoid from the fruit of Sinopodophyllum hexandrum

Yue Kong; Jun-Jun Xiao; Shu-Cong Meng; Xiao-Min Dong; Yue-Wei Ge; Ru-Feng Wang; Ming-Ying Shang; Shao-Qing Cai

doi:10.1016/j.fitote.2009.11.003

A new cytotoxic flavonoid from the fruit of Sinopodophyllum hexandrum

Fitoterapia. 2010 Jul;81(5):367-70. doi: 10.1016/j.fitote.2009.11.003. Epub 2009 Nov 10.

Authors

Yue Kong¹, Jun-Jun Xiao, Shu-Cong Meng, Xiao-Min Dong, Yue-Wei Ge, Ru-Feng Wang, Ming-Ying Shang, Shao-Qing Cai

Affiliation

¹ Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, China.

PMID: 19909799
DOI: 10.1016/j.fitote.2009.11.003

Abstract

Constituents of the fruit of Sinopodophyllum hexandrum (Royle) Ying (Sinopodophylli Fructus) were investigated. A new flavonoid, 8,2'-diprenylquercetin 3-methyl ether along with 9 known compounds were isolated and identified. Among them, the new compound 8,2'-diprenylquercetin 3-methyl ether exhibited cytotoxic activities against MDA-231 and T47D breast cancer cell lines, quercetin, kaempferol and rutin were isolated from Sinopodophylli Fructus for the first time.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology
Antineoplastic Agents, Phytogenic / therapeutic use*
Berberidaceae / chemistry*
Breast Neoplasms / drug therapy*
Cell Line, Tumor
Female
Flavonoids / isolation & purification
Flavonoids / pharmacology
Flavonoids / therapeutic use
Fruit
Humans
Kaempferols / isolation & purification
Phytotherapy*
Plant Extracts / isolation & purification
Plant Extracts / pharmacology
Plant Extracts / therapeutic use*
Quercetin / analogs & derivatives*
Quercetin / isolation & purification
Quercetin / pharmacology
Quercetin / therapeutic use
Rutin / isolation & purification

Substances

8,2'-diprenylquercetin 3-methyl ether
Antineoplastic Agents, Phytogenic
Flavonoids
Kaempferols
Plant Extracts
Rutin
kaempferol
Quercetin