Synthesis and biological evaluation of dehydroabietic acid derivatives

Eur J Med Chem. 2010 Feb;45(2):811-6. doi: 10.1016/j.ejmech.2009.10.010. Epub 2009 Oct 13.

Abstract

A series of C18-oxygenated derivatives of dehydroabietic acid were synthesized from commercial abietic acid and evaluated for their cytotoxic, antimycotic, and antiviral activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abietanes / chemical synthesis
  • Abietanes / chemistry*
  • Abietanes / pharmacology*
  • Animals
  • Antifungal Agents / chemical synthesis
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Antiviral Agents / chemical synthesis
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology
  • Cell Line, Tumor
  • Fungi / drug effects
  • Herpesvirus 1, Human / drug effects
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Inhibitory Concentration 50
  • Microbial Sensitivity Tests

Substances

  • Abietanes
  • Antifungal Agents
  • Antineoplastic Agents
  • Antiviral Agents
  • dehydroabietic acid
  • abietic acid