Lack of association between antipsychotic-induced extrapyramidal symptoms and polymorphisms in dopamine metabolism and transport genes

Patricia Gassó; Sergi Mas; Anna Crescenti; Santi Alvarez; Gemma Parramon; Clemente Garcia-Rizo; Eduard Parellada; Miquel Bernardo; Amalia Lafuente

doi:10.1016/j.psychres.2009.07.006

Lack of association between antipsychotic-induced extrapyramidal symptoms and polymorphisms in dopamine metabolism and transport genes

Psychiatry Res. 2010 Jan 30;175(1-2):173-5. doi: 10.1016/j.psychres.2009.07.006. Epub 2009 Nov 5.

Authors

Patricia Gassó¹, Sergi Mas, Anna Crescenti, Santi Alvarez, Gemma Parramon, Clemente Garcia-Rizo, Eduard Parellada, Miquel Bernardo, Amalia Lafuente

Affiliation

¹ Dept. Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Barcelona, Spain.

PMID: 19892410
DOI: 10.1016/j.psychres.2009.07.006

Abstract

The purpose of this study was to investigate the relationship between functional polymorphisms in genes coding for dopamine metabolism and transport enzymes and the incidence of acute antipsychotic (AP)-induced extrapyramidal symptoms (EPS). We did not find evidence of the involvement of these polymorphisms in the predisposition towards or protection from EPS.

MeSH terms

Antipsychotic Agents / adverse effects*
Basal Ganglia Diseases / chemically induced*
Basal Ganglia Diseases / genetics*
Dopamine Plasma Membrane Transport Proteins / genetics*
Gene Frequency
Genome-Wide Association Study
Genotype
Humans
Mental Disorders / drug therapy
Minisatellite Repeats / genetics
Monoamine Oxidase / genetics*
Multivariate Analysis
Polymorphism, Genetic / genetics*
Retrospective Studies

Substances

Antipsychotic Agents
Dopamine Plasma Membrane Transport Proteins
Monoamine Oxidase