Abstract
Scytoscalarol (1), a antimicrobial sesterterpene bearing a guanidino group, was isolated from the cultured cyanobacterium Scytonema sp. (UTEX 1163) by bioassay-guided fractionation. The chemical structure was determined by spectroscopic analysis including MS and 1D and 2D NMR. Scytoscalarol (1) showed antimicrobial activities against Bacillus anthracis, Staphylococcus aureus, Escherichia coli, Candida albicans, and Mycobacterium tuberculosis with MIC values in the range from 2 to 110 microM.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology*
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Bacillus anthracis / drug effects
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Candida albicans / drug effects
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Cyanobacteria / chemistry*
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Escherichia coli / drug effects
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Guanidines / chemistry
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Guanidines / isolation & purification*
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Guanidines / pharmacology*
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Microbial Sensitivity Tests
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Molecular Structure
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Mycobacterium tuberculosis / drug effects
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Nuclear Magnetic Resonance, Biomolecular
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Sesterterpenes / chemistry
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Sesterterpenes / isolation & purification*
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Sesterterpenes / pharmacology*
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Staphylococcus aureus / drug effects
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Guanidines
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Sesterterpenes
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scytoscalarol