Abstract
1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines were prepared. Binding assays indicated they are 5-HT(6) receptor ligands, among which 6f and 6g showed high affinity for 5-HT(6) receptors with K(i)=3.9 and 1.7 nM, respectively.
MeSH terms
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HeLa Cells
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Humans
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Ligands
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Pyridines / chemistry
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Pyridines / pharmacology*
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Pyrroles / chemistry
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Pyrroles / pharmacology*
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Receptors, Serotonin / drug effects*
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Receptors, Serotonin / metabolism
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Serotonin Antagonists / chemistry
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Serotonin Antagonists / pharmacology*
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Serotonin Receptor Agonists / chemistry
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Serotonin Receptor Agonists / pharmacology*
Substances
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Ligands
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Pyridines
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Pyrroles
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Receptors, Serotonin
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Serotonin Antagonists
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Serotonin Receptor Agonists
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serotonin 6 receptor
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pyrrolo(2, 3-b)pyridine