Abstract
An asymmetric direct aldol reaction of acetoacetals is described. Under the catalysis of a simple chiral primary amine, the direct aldol reactions of acetoacetals occur exclusively on the gamma-position to give vinylogous-type aldol products with high diastereo- and enantioselectivity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetals / chemistry*
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Acetates / chemistry*
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Aldehydes / chemistry*
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Amines / chemistry*
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Biological Products / chemical synthesis
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Biological Products / chemistry
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Catalysis
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Chromatography, High Pressure Liquid
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Ketones / chemistry
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Macrolides / chemical synthesis
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Macrolides / chemistry
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Magnetic Resonance Spectroscopy
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Solvents / chemistry
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Stereoisomerism
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Vinyl Compounds / chemistry
Substances
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Acetals
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Acetates
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Aldehydes
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Amines
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Biological Products
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Ketones
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Macrolides
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Solvents
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Vinyl Compounds
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3-hydroxybutanal