Abstract
Chemical investigation on the whole plant of Houttuynia cordata has resulted in the isolation of two new compounds, named as houttuynoside A (1) and houttuynamide A (2), together with thirty-eight known compounds. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. In the inhibitory effects on herpes simplex virus type 1 (HSV-1) assay, norcepharadione B (10) showed good inhibitory activity against the replication of HSV-1. In addition, the antioxidant and antityrosinase activities of some isolated compounds were also evaluated. Among these compounds, quercitrin (25) and quercetin-3-O-beta-D-galactopyranoside (26) showed excellent 2,2-diphenyl-1-picrylhydrazyl radical-scavenging property with IC50 values of 31 and 63 microM, respectively. Cepharadione B (9) exhibited strong tyrosinase inhibitory activity with an IC50 value of 170 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / chemistry
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Antioxidants / isolation & purification
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Antioxidants / pharmacology*
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Antiviral Agents / chemistry
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Antiviral Agents / isolation & purification
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Antiviral Agents / pharmacology*
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Benzamides / chemistry
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Benzamides / isolation & purification
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Benzamides / pharmacology*
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Benzoates / chemistry
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Benzoates / isolation & purification
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Benzoates / pharmacology*
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Chlorocebus aethiops
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Dose-Response Relationship, Drug
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Glucosides / chemistry
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Glucosides / isolation & purification
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Glucosides / pharmacology*
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Herpesvirus 1, Human / drug effects*
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Houttuynia / chemistry*
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Isoquinolines / chemistry
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Isoquinolines / isolation & purification
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Isoquinolines / pharmacology
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Microbial Sensitivity Tests
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Monophenol Monooxygenase / antagonists & inhibitors
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Plants, Medicinal / chemistry
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Quercetin / analogs & derivatives
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Quercetin / chemistry
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Quercetin / isolation & purification
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Quercetin / pharmacology
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Structure-Activity Relationship
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Vero Cells
Substances
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Antioxidants
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Antiviral Agents
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Benzamides
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Benzoates
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Enzyme Inhibitors
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Glucosides
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Isoquinolines
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houttuynamide A
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houttuynoside A
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quercitrin
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norcepharadione B
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Quercetin
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Monophenol Monooxygenase