Chasing after antibiotic leads

Anna-Skrollan Geiermann; Ronald Micura

doi:10.1016/j.chembiol.2009.10.001

Chasing after antibiotic leads

Chem Biol. 2009 Oct 30;16(10):1024-5. doi: 10.1016/j.chembiol.2009.10.001.

Authors

Anna-Skrollan Geiermann¹, Ronald Micura

Affiliation

¹ Institute of Organic Chemistry, Center for Molecular Biosciences (CMBI), University of Innsbruck, 6020 Innsbruck, Austria.

PMID: 19875074
DOI: 10.1016/j.chembiol.2009.10.001

Abstract

The emergence of drug-resistant pathogens has prompted the search for new antibacterials. In this issue of Chemistry & Biology, Starosta et al. identify specific thiopeptide-antibiotic precursor lead compounds using three complementary high-throughput translation machinery assays.

Publication types

Comment

MeSH terms

Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology
Drug Resistance, Multiple, Bacterial
Peptidyl Transferases / antagonists & inhibitors
Peptidyl Transferases / metabolism
Ribosomes / chemistry
Ribosomes / metabolism*
Sulfhydryl Compounds / chemistry
Thiostrepton / chemistry
Thiostrepton / pharmacology

Substances

Anti-Bacterial Agents
Sulfhydryl Compounds
Peptidyl Transferases
Thiostrepton