Objective: To prepare Maiyanning sustained-release patches and optimize the prescription.
Method: The mono-factor design was used to screen the formulation of the sustained-release patches.
Result: The optimal composition of the formulation was MD-607 as the pressure sensitive adhesive and azone as the penetration enhancer with the content of 5.0%. Drugs released from the pressure-sensitive adhesive patches in a constant speed, it confirmed that the drug was released by zero order equation from the patches.
Conclusion: The prepared patches have an ideal release trait.