Antiretroviral strategies to prevent mother-to-child transmission of HIV: striking a balance between efficacy, feasibility, and resistance

PLoS Med. 2009 Oct;6(10):e1000169. doi: 10.1371/journal.pmed.1000169. Epub 2009 Oct 27.

Abstract

Dara Lehman and colleagues discuss a randomized trial that found that adding up to a week of twice-daily zidovudine+lamivudine to single-dose nevirapine reduces the risk of resistance in mothers and infants.

Publication types

  • Comment

MeSH terms

  • Anti-HIV Agents / therapeutic use
  • Antiretroviral Therapy, Highly Active
  • Drug Resistance, Viral*
  • Female
  • HIV Infections / prevention & control*
  • HIV Infections / transmission
  • HIV-1 / drug effects*
  • Humans
  • Infectious Disease Transmission, Vertical / prevention & control*
  • Lamivudine / therapeutic use
  • Nevirapine / therapeutic use
  • Pregnancy
  • Pregnancy Complications, Infectious / prevention & control*
  • Pregnancy Complications, Infectious / virology
  • Zidovudine / therapeutic use

Substances

  • Anti-HIV Agents
  • Lamivudine
  • Zidovudine
  • Nevirapine