Abstract
In recent years an apparent increase in the frequency of detection of G3P[8] rotaviruses has been observed worldwide. Similarly, in Italy G3P[8] strains have been detected sporadically and in a scattered fashion over 20 years, whereas in 2003 and 2005 G3P[8] rotavirus activity increased markedly. By analysis of the VP7, VP4, VP6, and NSP4 genes of a selection of G3P[8] rotaviruses detected between 1993 and 2005, a remarkable sequence conservation was observed in the VP7, VP4, and VP6 genes. By converse, after 2002 the Italian G3P[8] strains were found to possess unique mutations in significant regions of the NSP4 protein.
(c) 2009 Wiley-Liss, Inc.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Antigens, Viral / analysis
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Antigens, Viral / genetics
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Capsid Proteins / analysis
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Capsid Proteins / genetics
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Child, Preschool
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Feces / virology
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Glycoproteins / analysis
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Glycoproteins / genetics
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Humans
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Infant
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Infant, Newborn
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Italy / epidemiology
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Molecular Sequence Data
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Phylogeny
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RNA, Viral / genetics
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RNA, Viral / isolation & purification
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Rotavirus / genetics*
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Rotavirus Infections* / epidemiology
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Rotavirus Infections* / virology
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Sequence Analysis, RNA
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Toxins, Biological / analysis
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Toxins, Biological / genetics
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Viral Nonstructural Proteins / analysis
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Viral Nonstructural Proteins / genetics
Substances
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Antigens, Viral
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Capsid Proteins
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Glycoproteins
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NS28 protein, rotavirus
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RNA, Viral
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Toxins, Biological
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VP4 protein, Rotavirus
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VP6 protein, Rotavirus
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VP7 protein, Rotavirus
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Viral Nonstructural Proteins