Abstract
Helicobacter heilmannii (Hh) has been clinically reported to have some relation to gastric low grade MALT lymphoma. Recently, we have formed the gastric MALT lymphoma in C57BL/6 mice.
Materials and methods:
C57BL/6 mice infected with Hh from cynomolgus monkey for more than 6 months were used. The macroscopic, immunohistochemical and electron microscopic observation was performed
Results:
MALT lymphoma was formed in almost 100% of the infected mice. Increased VEGF-A and Flt-3 immunoreactivity was recognized.
Conclusion:
Hh was shown to be related to the formation of MALT lymphoma and VEGF is suggested to play a role in this lymphoma.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Helicobacter Infections / complications*
-
Helicobacter heilmannii*
-
Lymphoma, B-Cell, Marginal Zone / etiology*
-
Lymphoma, B-Cell, Marginal Zone / pathology
-
Mice
-
Mice, Inbred C3H
-
Mice, Inbred C57BL
-
Stomach / pathology
-
Stomach Neoplasms / etiology*
-
Stomach Neoplasms / pathology
-
Vascular Endothelial Growth Factor A / analysis
-
Vascular Endothelial Growth Factor A / physiology*
-
Vascular Endothelial Growth Factor Receptor-2 / analysis
Substances
-
Vascular Endothelial Growth Factor A
-
vascular endothelial growth factor A, mouse
-
Vascular Endothelial Growth Factor Receptor-2