The role of Runx1/AML1 and Evi-1 in the regulation of hematopoietic stem cells

J Cell Physiol. 2010 Feb;222(2):282-5. doi: 10.1002/jcp.21953.

Abstract

Lineage-specific transcription factors must be precisely regulated during stem cell self-renewal and lineage commitment decisions. The role of specific transcription factors in hematopoietic stem cell (HSC) fate decisions has derived largely from genetic strategies, primarily gene-targeting and transgenic or retroviral overexpression experiments. From the previous experimental results, several transcription factors have been found to play critical roles in HSC physiology. Among them, we focus two transcription factors, Runx1/AML1 and Evi-1, in this review. During embryogenesis, both Runx1 and Evi-1 are essential for HSCs whereas in the adult, Runx1 and Evi-1 regulate HSCs negatively and positively, respectively.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Adult Stem Cells / metabolism*
  • Animals
  • Cell Differentiation
  • Cell Lineage
  • Cell Proliferation
  • Core Binding Factor Alpha 2 Subunit / genetics
  • Core Binding Factor Alpha 2 Subunit / metabolism*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Embryonic Stem Cells / metabolism*
  • Gene Expression Regulation, Developmental
  • Hematopoiesis* / genetics
  • Hematopoietic Stem Cells / metabolism*
  • Humans
  • MDS1 and EVI1 Complex Locus Protein
  • Proto-Oncogenes / genetics
  • Signal Transduction* / genetics
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • Core Binding Factor Alpha 2 Subunit
  • DNA-Binding Proteins
  • MDS1 and EVI1 Complex Locus Protein
  • MECOM protein, human
  • Mecom protein, mouse
  • Transcription Factors