This Nano Focus article reviews recent developments in nanofabrication based on invited talks given at the "Chemical Methods of Nanofabrication" symposium, which was organized by the authors and presented at the 237th ACS National Meeting and Exhibition as one of seven symposia within the meeting theme, "Nanoscience: Challenges for the Future". The three-day symposium included 25 experts from academia, national laboratories, and industry from around the world, to discuss current progress and future directions in nanofabrication. We highlight several of the key results discussed and future directions and challenges in this rapidly changing field.