Abstract
Viral subversion and inhibition of host cell autophagy has been documented for several viruses. In this issue of Cell Host & Microbe,Gannagé et al. (2009) show that the influenza virus M2 integral membrane protein blocks autophagosome maturation, significantly affecting host cell apoptosis.
Publication types
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Comment
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Apoptosis*
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Autophagy*
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Humans
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Influenza A virus / pathogenicity*
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Lysosomes / metabolism*
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Lysosomes / ultrastructure
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Models, Biological
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Phagosomes / metabolism*
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Phagosomes / ultrastructure
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Viral Matrix Proteins / physiology*
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Virulence Factors / physiology*
Substances
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M2 protein, Influenza A virus
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Viral Matrix Proteins
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Virulence Factors