Autophagy, apoptosis, and the influenza virus M2 protein

Cell Host Microbe. 2009 Oct 22;6(4):299-300. doi: 10.1016/j.chom.2009.09.009.

Abstract

Viral subversion and inhibition of host cell autophagy has been documented for several viruses. In this issue of Cell Host & Microbe,Gannagé et al. (2009) show that the influenza virus M2 integral membrane protein blocks autophagosome maturation, significantly affecting host cell apoptosis.

Publication types

  • Comment
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Autophagy*
  • Humans
  • Influenza A virus / pathogenicity*
  • Lysosomes / metabolism*
  • Lysosomes / ultrastructure
  • Models, Biological
  • Phagosomes / metabolism*
  • Phagosomes / ultrastructure
  • Viral Matrix Proteins / physiology*
  • Virulence Factors / physiology*

Substances

  • M2 protein, Influenza A virus
  • Viral Matrix Proteins
  • Virulence Factors