We provided pharmaceutical care for a cryptococcal meningitis case to study the role that clinical pharmacists played in clinical pharmacotherapy. In this case, clinical pharmacists gave advice on drug therapy strategy which was mostly accepted by physicians. During the whole course of drug treatment, focused on monitoring, prevention, and treatment of adverse reactions, clinical pharmacists carried out pharmaceutical care on efficacy, safety, economics and compliance of drug therapy. After 73 days' treatment, with CSF cryptococcal count negative twice and physical condition improved, the patient was discharged. No serious adverse reaction was observed in the period of treatment. The total pharmaceutical care was completed as planned. Through participating in the formulation of treatment strategy and carrying out pharmaceutical care, clinical pharmacists can play a role in improving the efficacy and safety of drug therapy in cryptococcal meningitis.