The authors analyse the results of 363 patients, who underwent surgery for pancreatic or periampullary tumours. There were 175 operable and 188 inoperable cases. The preoperative data (age, gender, site of the tumour, characteristic clinical signs), as well as surgical methods are overviewed. A pancreatoduodenectomy was most frequently applied as a curative surgery, while double-bypass was mainly performed for palliation. As far as postoperative complications, especially the rate of pancreatic fistula, which is influenced by the anastomotic method, are discussed. Reoperation and early postoperative mortality rate was 5,7% and 4,5% in the operable cases, respectively. These numbers were 1,6% and 6,9% among the inoperable cases. Following radical procedure adjuvant therapy followed surgical treatment, its results are also reported. In summary, curative surgical therapy and postoperative adjuvant treatment are necessary for a chance of long-term survival.