Abstract
HIC1 (Hypermethylated In Cancer 1) is a tumor suppressor gene which is epigenetically inactivated in many human cancers. HIC1 encodes a transcriptional repressor comprising an N-terminal BTB/POZ domain and a C-terminal DNA binding domain containing five Krüppel-like C(2)H(2) zinc fingers. To date, few HIC1 target genes are known and the regulation of HIC1 activity is not fully deciphered. However, a growing list of studies, summarized in this review, strongly suggest that HIC1 plays a central role in the DNA damage response through the establishment of several complex regulatory loops involving HIC1, p53, SIRT1 and E2F1.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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DNA Damage / genetics
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DNA Damage / physiology*
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DNA Repair / genetics
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DNA Repair / physiology*
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E2F1 Transcription Factor / genetics
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E2F1 Transcription Factor / physiology*
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Gene Silencing
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Humans
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Kruppel-Like Transcription Factors / genetics
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Kruppel-Like Transcription Factors / physiology*
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Repressor Proteins / genetics
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Repressor Proteins / physiology
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Sirtuin 1 / physiology*
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Transcription, Genetic / physiology
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Tumor Suppressor Protein p53 / genetics
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Tumor Suppressor Protein p53 / physiology*
Substances
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E2F1 Transcription Factor
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E2F1 protein, human
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HIC1 protein, human
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Kruppel-Like Transcription Factors
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Repressor Proteins
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Tumor Suppressor Protein p53
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SIRT1 protein, human
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Sirtuin 1