Abstract
We describe herein the synthesis and the biological evaluation of a novel series of a potent anticancer agents: the tripentones. For the first time, a halogen atom was introduced in high yields on the pyrrole ring of the tricycle. This synthesis and the reactivity of the novel halogenated tripentones in metallo-catalysed cross-coupling reactions will be described in that article. Finally their influence on biological activity will be discussed.
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cross-Linking Reagents / chemistry
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Drug Evaluation, Preclinical
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Humans
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Hydrocarbons, Halogenated / chemical synthesis
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Hydrocarbons, Halogenated / chemistry
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Hydrocarbons, Halogenated / pharmacology*
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Pyrrolizidine Alkaloids / chemical synthesis
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Pyrrolizidine Alkaloids / chemistry
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Pyrrolizidine Alkaloids / pharmacology*
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Cross-Linking Reagents
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Hydrocarbons, Halogenated
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Pyrrolizidine Alkaloids