Antibiotics for community-acquired pneumonia

J Antimicrob Chemother. 2009 Dec;64(6):1123-5. doi: 10.1093/jac/dkp359. Epub 2009 Oct 10.

Abstract

Antibiotic guidelines for community-acquired pneumonia (CAP) often recommend broad-spectrum agents for severe pneumonia. While these may be entirely appropriate in terms of their spectrum of activity and efficacy, there is a risk that such recommendations could result in over-prescribing of broad-spectrum agents with consequent 'collateral damage', meaning superinfection by resistant pathogens, or selection of antibiotic resistance. Narrow-spectrum agents are often as effective and result in less collateral damage. National and local antibiotic guidance should promote choices of agents for narrow-spectrum prescribing even for severe CAP where appropriate.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Community-Acquired Infections / drug therapy*
  • Drug Resistance, Bacterial
  • Guidelines as Topic
  • Humans
  • Pneumonia / drug therapy*

Substances

  • Anti-Bacterial Agents