Abstract
In this case-control study the association between the PTPN22 1858T and CTLA-4 49G gene variants and T1D in Croatian population was examined. We found that distribution of PTPN22 C1858T and CTLA-4 A49G genotypes between T1D patient (n=102) and control (n=193) groups differ significantly (p<0.0001 and p=0.012, respectively). Moreover, although the risk alleles of both SNPs are distributed more frequently in patients, the significant difference is observed only for PTPN22 1858T allele (p<0.0001). This is therefore the first evidence that analyzed gene variants contribute to T1D pathogenesis in Croatian population.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenine
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Adult
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Age of Onset
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Antigens, CD / genetics*
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Blood Glucose / analysis
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CTLA-4 Antigen
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Croatia
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Cytosine
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DNA Primers
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Diabetes Mellitus, Type 1 / blood
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Diabetes Mellitus, Type 1 / epidemiology
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Diabetes Mellitus, Type 1 / genetics*
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Genetic Variation
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Genotype
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Glycated Hemoglobin / analysis
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Guanine
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Humans
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Polymerase Chain Reaction
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Polymorphism, Genetic*
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Polymorphism, Single Nucleotide*
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Reference Values
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Risk Assessment
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Thymine
Substances
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Antigens, CD
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Blood Glucose
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CTLA-4 Antigen
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CTLA4 protein, human
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DNA Primers
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Glycated Hemoglobin A
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Guanine
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Cytosine
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Adenine
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Thymine