Association of PTPN22 C1858T and CTLA-4 A49G polymorphisms with Type 1 Diabetes in Croatians

Diabetes Res Clin Pract. 2009 Dec;86(3):e54-7. doi: 10.1016/j.diabres.2009.09.012. Epub 2009 Oct 7.

Abstract

In this case-control study the association between the PTPN22 1858T and CTLA-4 49G gene variants and T1D in Croatian population was examined. We found that distribution of PTPN22 C1858T and CTLA-4 A49G genotypes between T1D patient (n=102) and control (n=193) groups differ significantly (p<0.0001 and p=0.012, respectively). Moreover, although the risk alleles of both SNPs are distributed more frequently in patients, the significant difference is observed only for PTPN22 1858T allele (p<0.0001). This is therefore the first evidence that analyzed gene variants contribute to T1D pathogenesis in Croatian population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine
  • Adult
  • Age of Onset
  • Antigens, CD / genetics*
  • Blood Glucose / analysis
  • CTLA-4 Antigen
  • Croatia
  • Cytosine
  • DNA Primers
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / epidemiology
  • Diabetes Mellitus, Type 1 / genetics*
  • Genetic Variation
  • Genotype
  • Glycated Hemoglobin / analysis
  • Guanine
  • Humans
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Polymorphism, Single Nucleotide*
  • Reference Values
  • Risk Assessment
  • Thymine

Substances

  • Antigens, CD
  • Blood Glucose
  • CTLA-4 Antigen
  • CTLA4 protein, human
  • DNA Primers
  • Glycated Hemoglobin A
  • Guanine
  • Cytosine
  • Adenine
  • Thymine