C5-functionalized LNA: unparalleled hybridization properties and enzymatic stability

Chembiochem. 2009 Nov 23;10(17):2740-3. doi: 10.1002/cbic.200900500.

Authors

Michael E Østergaard¹, Pawan Kumar, Bharat Baral, Daniel J Raible, T Santhosh Kumar, Brooke A Anderson, Dale C Guenther, Lee Deobald, Andrzej J Paszczynski, Pawan K Sharma, Patrick J Hrdlicka

Affiliation

¹ Chemistry Department, University of Idaho, P. O. Box 442343, Moscow, ID 83844-2343, USA.

PMID: 19810078
DOI: 10.1002/cbic.200900500

No abstract available

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Base Pairing
DNA / chemistry
Enzyme Stability
Molecular Structure
Nucleic Acid Conformation*
Oligonucleotides / chemistry*
Oligonucleotides / genetics
Oligonucleotides / metabolism*
Organophosphorus Compounds / chemical synthesis
Organophosphorus Compounds / chemistry
RNA / chemistry

Substances

Oligonucleotides
Organophosphorus Compounds
locked nucleic acid
phosphoramidite
RNA
DNA