Effect of cefatrizine and cephaloglycine on L-leucine absorption in rat jejunum

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1990;96(2):317-20. doi: 10.1016/0742-8413(90)90014-z.

Abstract

1. The oral cephalosporins: cefatrizine and cephaloglycine inhibit the L-leucine absorption in vivo on rat jejunum. 2. This inhibition is dose and time dependent and the effect is irreversible. 3. These antibiotics have a systemic effect on L-leucine absorption. 4. The inhibition of these antibiotics affect only leucine transport, without affecting the diffusion. 5. Cefatrizine and cephaloglycine inhibit the basolateral (Na(+)-K+) ATPase activity in rat jejunum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Transport, Active / drug effects
  • Cefatrizine / pharmacology*
  • Cephaloglycin / pharmacology*
  • Intestinal Absorption / drug effects*
  • Jejunum / metabolism*
  • Leucine / pharmacokinetics*
  • Male
  • Rats
  • Rats, Inbred Strains
  • Sodium-Potassium-Exchanging ATPase / drug effects

Substances

  • Cefatrizine
  • Sodium-Potassium-Exchanging ATPase
  • Leucine
  • Cephaloglycin