Abstract
Two novel SF5 analogs of the antimalarial agent mefloquine were synthesized in 5 steps and 10-23% overall yields and found to have improved activity and selectivity against malaria parasites. This work also represents the first report of SF5-substituted quinolines.
MeSH terms
-
Animals
-
Antimalarials / chemical synthesis*
-
Antimalarials / chemistry
-
Antimalarials / pharmacology*
-
Antimalarials / toxicity
-
Mefloquine / analogs & derivatives
-
Mefloquine / chemical synthesis*
-
Mefloquine / pharmacology*
-
Mefloquine / toxicity
-
Models, Molecular
-
Molecular Conformation
-
Plasmodium falciparum / drug effects