This article reviews current data available on the Mediterranean diet related to its use in a diabetic population. Based on many published reports, it is apparent that the Mediterranean diet may be used in dietary interventions for the treatment of overweight and obesity, conditions associated with the development of type 2 diabetes. In addition, obesity in type 2 diabetic persons is associated with other cardiovascular disease risk factors. The Mediterranean diet has been found to be inversely related to the metabolic syndrome, often a feature of diabetic individuals. Perhaps the most critical information placing the Mediterranean diet in a favorable position is the positive response of insulin, blood glucose, blood lipids, and other metabolic factors predicting cardiovascular disease risk and outcomes. This diet is a viable treatment option; advisors should stress not only adherence to a fairly traditional Mediterranean eating plan but also a lifestyle that includes sufficient physical activity.