New caloporoside derivatives and their inhibition of fungal spore germination

Z Naturforsch C J Biosci. 2009 Jul-Aug;64(7-8):521-5. doi: 10.1515/znc-2009-7-810.

Abstract

In our ongoing screening culture fluid extracts of Gloeoporus (Caloporus) dichrous strain 83065 inhibited the germination of Magnaporthe grisea and Fusarium graminearum spores. While isolating the active metabolites two new caloporosides, caloporoside G and caloporoside H, in addition to the known caloporoside derivatives F-16438G, caloporoside A, and 2-hydroxy-6-(16-hydroxyheptadecyl)benzoic acid were obtained.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antifungal Agents / pharmacology
  • Cell Line, Tumor / drug effects
  • Humans
  • Jurkat Cells / drug effects
  • Leukemia L1210 / pathology
  • Magnetic Resonance Spectroscopy
  • Mannose / analogs & derivatives*
  • Mannose / chemistry
  • Mannose / pharmacology
  • Mice
  • Salicylates / chemistry
  • Salicylates / pharmacology*
  • Spores, Fungal / drug effects
  • Spores, Fungal / physiology*
  • Type C Phospholipases / antagonists & inhibitors

Substances

  • Antifungal Agents
  • Salicylates
  • caloporoside
  • Type C Phospholipases
  • Mannose