Amino and nitro derivatives of 5,7-dimethoxyflavone from Kaempferia parviflora and cytotoxicity against KB cell line

Suchana Wanich; Chavi Yenjai

doi:10.1007/s12272-009-1901-y

Amino and nitro derivatives of 5,7-dimethoxyflavone from Kaempferia parviflora and cytotoxicity against KB cell line

Arch Pharm Res. 2009 Sep;32(9):1185-9. doi: 10.1007/s12272-009-1901-y. Epub 2009 Sep 26.

Authors

Suchana Wanich¹, Chavi Yenjai

Affiliation

¹ Natural Products Research Unit, Center for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.

PMID: 19784572
DOI: 10.1007/s12272-009-1901-y

Abstract

Structural modification of 5,7-dimethoxyflavone isolated from Kaempferia parviflora furnished two nitro and seven amino derivatives. Among these, six new (3, 5-6, 8-10) and three known (2, 4, 7) flavonoid derivatives were synthesized. All compounds were evaluated for cytotoxicity against KB cell line using colorimetric method. Compounds 6 and 8 exhibited strong cytotoxicity with IC50 values of 6.80 and 5.84 microg/mL, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Flavonoids / pharmacology*
Humans
KB Cells
Magnetic Resonance Spectroscopy
Structure-Activity Relationship
Zingiberaceae / chemistry*

Substances

Antineoplastic Agents
Flavonoids
5,7-dimethoxyflavone