Abstract
Indolo[2,3-a]carbazole based inhibitors were synthesized from readily available indigo via a seven-step linear synthetic sequence with a moderate overall yield. The inhibitors were selectively and readily functionalized at the nitrogen on the indole portion of the carbazole unit. The synthesized analogs displayed moderate inhibitory activities toward Bacillus anthracis and Mycobacterium tuberculosis, indicating that indolo[2,3-a]carbazoles could serve as promising leads in the development of new drugs to combat anthrax and tuberculosis infections.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Anti-Bacterial Agents / chemical synthesis
-
Anti-Bacterial Agents / isolation & purification*
-
Anti-Bacterial Agents / pharmacology
-
Bacillus anthracis / drug effects
-
Biological Products / pharmacology*
-
Carbazoles / chemical synthesis
-
Carbazoles / isolation & purification*
-
Carbazoles / pharmacology
-
Drug Discovery*
-
Drug Evaluation, Preclinical
-
Ligands
-
Microbial Sensitivity Tests
-
Mycobacterium tuberculosis / drug effects
Substances
-
Anti-Bacterial Agents
-
Biological Products
-
Carbazoles
-
Ligands
-
6-cyano-5-methoxyindolo(2,3-a)carbazole