mir-210: a sensor for hypoxic stress during tumorigenesis

Mol Cell. 2009 Sep 24;35(6):737-8. doi: 10.1016/j.molcel.2009.09.008.

Abstract

In this issue of Molecular Cell, Huang et al. (2009) demonstrate that hypoxia-inducible mir-210 acts as a rheostat for cellular adaptation and survival by inhibiting tumor initiation.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Hypoxia
  • Cell Proliferation
  • Cell Transformation, Neoplastic / genetics*
  • Cell Transformation, Neoplastic / metabolism
  • Cell Transformation, Neoplastic / pathology
  • Gene Expression Regulation, Neoplastic*
  • Gene Silencing*
  • Genetic Therapy
  • Homeodomain Proteins / genetics
  • Homeodomain Proteins / metabolism
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit / genetics
  • Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
  • MicroRNAs / metabolism*
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Neoplasms / therapy
  • Protein Binding
  • Receptor, Fibroblast Growth Factor, Type 5 / genetics
  • Receptor, Fibroblast Growth Factor, Type 5 / metabolism
  • Stress, Physiological / genetics*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Transcription, Genetic
  • Up-Regulation

Substances

  • FGFRL1 protein, human
  • HIF1A protein, human
  • Homeodomain Proteins
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • MIRN210 microRNA, human
  • MicroRNAs
  • Receptor, Fibroblast Growth Factor, Type 5
  • Transcription Factors
  • homeobox A1 protein
  • homeobox protein HOXA9