Abstract
In this issue of Molecular Cell, Huang et al. (2009) demonstrate that hypoxia-inducible mir-210 acts as a rheostat for cellular adaptation and survival by inhibiting tumor initiation.
Publication types
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Comment
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Hypoxia
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Cell Proliferation
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Cell Transformation, Neoplastic / genetics*
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Cell Transformation, Neoplastic / metabolism
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Cell Transformation, Neoplastic / pathology
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Gene Expression Regulation, Neoplastic*
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Gene Silencing*
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Genetic Therapy
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Homeodomain Proteins / genetics
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Homeodomain Proteins / metabolism
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Humans
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Hypoxia-Inducible Factor 1, alpha Subunit / genetics
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Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
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MicroRNAs / metabolism*
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Neoplasms / genetics*
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Neoplasms / metabolism
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Neoplasms / pathology
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Neoplasms / therapy
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Protein Binding
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Receptor, Fibroblast Growth Factor, Type 5 / genetics
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Receptor, Fibroblast Growth Factor, Type 5 / metabolism
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Stress, Physiological / genetics*
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Transcription Factors / genetics
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Transcription Factors / metabolism
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Transcription, Genetic
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Up-Regulation
Substances
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FGFRL1 protein, human
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HIF1A protein, human
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Homeodomain Proteins
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Hypoxia-Inducible Factor 1, alpha Subunit
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MIRN210 microRNA, human
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MicroRNAs
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Receptor, Fibroblast Growth Factor, Type 5
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Transcription Factors
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homeobox A1 protein
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homeobox protein HOXA9