Co-delivery of doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells

Small. 2009 Dec;5(23):2673-7. doi: 10.1002/smll.200900621.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / administration & dosage
  • Apoptosis / drug effects
  • Cell Line, Tumor
  • Doxorubicin / administration & dosage*
  • Drug Resistance, Neoplasm
  • Female
  • Genes, bcl-2*
  • Humans
  • Microscopy, Electron, Transmission
  • Microscopy, Fluorescence
  • Nanoparticles* / chemistry
  • Nanoparticles* / ultrastructure
  • Nanotechnology
  • Ovarian Neoplasms / drug therapy
  • Ovarian Neoplasms / genetics
  • Ovarian Neoplasms / pathology
  • RNA, Small Interfering / administration & dosage*
  • RNA, Small Interfering / genetics*
  • Silicon Dioxide

Substances

  • Antineoplastic Agents
  • RNA, Small Interfering
  • Silicon Dioxide
  • Doxorubicin