Dipyridodiazepinone derivatives; synthesis and anti HIV-1 activity

Nisachon Khunnawutmanotham; Nitirat Chimnoi; Arunee Thitithanyanont; Patchreenart Saparpakorn; Kiattawee Choowongkomon; Pornpan Pungpo; Supa Hannongbua; Supanna Techasakul

doi:10.3762/bjoc.5.36

Dipyridodiazepinone derivatives; synthesis and anti HIV-1 activity

Beilstein J Org Chem. 2009 Jul 22:5:36. doi: 10.3762/bjoc.5.36.

Authors

Nisachon Khunnawutmanotham¹, Nitirat Chimnoi, Arunee Thitithanyanont, Patchreenart Saparpakorn, Kiattawee Choowongkomon, Pornpan Pungpo, Supa Hannongbua, Supanna Techasakul

Affiliation

¹ Chulabhorn Research Institute, Vibhavadee-Rangsit Highway, Bangkok 10210, Thailand.

Abstract

Ten dipyridodiazepinone derivatives were synthesized and evaluated for their anti HIV-1 reverse transcriptase activity against wild-type and mutant type enzymes, K103N and Y181C. Two of them were found to be promising inhibitors for HIV-1 RT.

Keywords: AIDS; anti HIV-1 RT; dipyridodiazepinone; nevirapine; synthesis.