Multicomponent reactions of dimethyl methoxymalonate and dialkyl acetylenedicarboxylate in the presence of N-nucleophiles: one-pot synthesis of 2H-pyridinyl-2-butenedioates in water

Mohammad A Khalilzadeh; Zinatossadat Hossaini; Samaneh Kharian

doi:10.1007/s11030-009-9192-2

Multicomponent reactions of dimethyl methoxymalonate and dialkyl acetylenedicarboxylate in the presence of N-nucleophiles: one-pot synthesis of 2H-pyridinyl-2-butenedioates in water

Mol Divers. 2010 Aug;14(3):605-9. doi: 10.1007/s11030-009-9192-2. Epub 2009 Sep 11.

Authors

Mohammad A Khalilzadeh¹, Zinatossadat Hossaini, Samaneh Kharian

Affiliation

¹ Chemistry Department, Islamic Azad University, Qaemshahr Branch, Mazandaran, Iran. m.khalilzadeh@hotmail.com

PMID: 19763860
DOI: 10.1007/s11030-009-9192-2

Abstract

An efficient synthesis of 2H-pyridinyl-2-butenedioate derivatives via reaction of dimethyl methoxymalonate and dialkyl acetylenedicarboxylate in the presence of N-nucleophiles in water as a solvent is described.

MeSH terms

Alkynes / chemical synthesis*
Alkynes / chemistry
Chemistry, Organic / methods*
Isoquinolines / chemistry
Malonates / chemical synthesis*
Malonates / chemistry
Pyridines / chemical synthesis*
Pyridines / chemistry
Water / chemistry*

Substances

Alkynes
Isoquinolines
Malonates
Pyridines
Water
acetylenedicarboxylic acid dimethyl ester