Abstract
Antigenemia in patients with Mediterranean visceral leishmaniasis (MVL) due to Leishmania infantum was retrospectively assessed by sandwich enzyme-linked immunosorbent assay (ELISA). Circulating Leishmania antigens, partially in free form, were in evidence in 53% of serum samples from immunocompetent individuals with MVL. Following successful therapy, antigenemia decline as measured by ELISA was more pronounced than antibody decrease.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Animals
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Antigens, Protozoan / blood*
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Antiprotozoal Agents / therapeutic use
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Enzyme-Linked Immunosorbent Assay / methods
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Female
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Humans
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Leishmania infantum / isolation & purification*
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Leishmaniasis, Visceral / blood*
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Leishmaniasis, Visceral / drug therapy
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Male
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Middle Aged
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Retrospective Studies
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Young Adult
Substances
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Antigens, Protozoan
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Antiprotozoal Agents