Regulation of duplex DNA strand displacement by visible light sensitive bis-peptide nucleic acid

Nucleic Acids Symp Ser (Oxf). 2009:(53):191-2. doi: 10.1093/nass/nrp096.

Abstract

A novel visible light sensitive azobenzene (AZO) was synthesized and introduced into bis-peptide nucleic acid (bis-PNA), which consists of two homopyrimidine PNA strands, as a linker. Visible light irradiation of the bis-PNA-AZO conjugate induced photoisomerization of the azobenzene moiety from trans to cis. The cis-form of bis-PNA-AZO displaced the complementary duplex DNA more efficiently than the trans-form.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azo Compounds / chemical synthesis
  • Azo Compounds / chemistry
  • Azo Compounds / radiation effects
  • DNA / chemistry*
  • Fluorescence Resonance Energy Transfer
  • Light*
  • Peptide Nucleic Acids / chemistry*
  • Peptide Nucleic Acids / radiation effects

Substances

  • Azo Compounds
  • Peptide Nucleic Acids
  • DNA
  • azobenzene