Synthesis and properties of new RNA molecules incorporating 2'-O-aryluridine derivatives

Nucleic Acids Symp Ser (Oxf). 2009:(53):117-8. doi: 10.1093/nass/nrp059.

Abstract

A variety of 2'-O-arylnucleosides with functional groups were synthesized by the microwave-assisted reaction of 2,2'-anhydrouridine with phenol derivatives. The 2'-O-arylnucleosides thus obtained were incorporated into 2'-O-Me RNA or DNA oligomers and their hybridization properties were studied by T(m) measurements.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA / chemistry
  • Nucleosides / chemical synthesis
  • Nucleosides / chemistry
  • RNA / chemical synthesis
  • RNA / chemistry*
  • Uridine / analogs & derivatives*
  • Uridine / chemistry

Substances

  • Nucleosides
  • RNA
  • DNA
  • Uridine