Directed evolution of orthogonal ligand specificity in a single scaffold

Angew Chem Int Ed Engl. 2009;48(42):7783-6. doi: 10.1002/anie.200903413.
No abstract available

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Directed Molecular Evolution / methods*
  • Estradiol / chemistry
  • Estradiol / pharmacology
  • Estrogen Receptor alpha / agonists*
  • Estrogen Receptor alpha / genetics
  • Estrogen Receptor alpha / metabolism
  • Gene Expression*
  • Humans
  • Ligands
  • Mutagenesis
  • Phenylglyoxal / analogs & derivatives
  • Phenylglyoxal / chemistry
  • Phenylglyoxal / pharmacology
  • Protein Structure, Tertiary / genetics
  • Thiazoles / chemistry
  • Thiazoles / pharmacology
  • Two-Hybrid System Techniques

Substances

  • 2,4-di(4-hydroxyphenyl)-5-ethylthiazole
  • 4,4'-dihydroxybenzil
  • Estrogen Receptor alpha
  • Ligands
  • Thiazoles
  • Estradiol
  • Phenylglyoxal