Abstract
Seven new guanidine alkaloids (1-7) together with the known batzelladines A, F, H, and L, ptilomycalin A, and fromiamycalin were isolated from the Caribbean marine sponges Monanchora arbuscula and Clathria calla. Molecular structures were assigned on the basis of detailed analysis of 1D and 2D NMR spectra and mass spectrometry data, and bioactivities of the alkaloids were evaluated against human cancer cell lines and malaria protozoa.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Antimalarials / chemistry
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Antimalarials / isolation & purification*
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Antimalarials / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Chloroquine / pharmacology
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Drug Resistance
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Drug Screening Assays, Antitumor
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Guanidines / chemistry
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Guanidines / isolation & purification*
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Guanidines / pharmacology
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Humans
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Marine Biology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plasmodium falciparum / drug effects
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Porifera / chemistry
Substances
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Alkaloids
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Antimalarials
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Antineoplastic Agents
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Guanidines
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Chloroquine