Assessment of photon migration in scattering media using heterodyning techniques with a frequency modulated diode laser

Opt Express. 2009 Aug 31;17(18):16291-9. doi: 10.1364/OE.17.016291.

Abstract

A novel technique for studying photon propagation in scattering media is proposed and demonstrated, as is believed, for the first time. Photons propagating through the medium, from a frequency-ramped single-mode diode laser, meet a reference beam from the same source, at a common detector, and beat frequencies corresponding to various temporal delays are observed by heterodyne techniques. Fourier transformation directly yields the temporal dispersion curve. Proof-of-principle experiments on polystyrene foam and a tissue phantom suggest, that the new method, when fully developed, may favorably compete with the more complex time-correlated single-photon counting (TCSPC) and the phase-shift methods, now much employed.

Publication types

  • Research Support, Non-U.S. Gov't