Steroid hormone pulsing drives cyclic gene expression

Nat Cell Biol. 2009 Sep;11(9):1051-3. doi: 10.1038/ncb0909-1051.

Abstract

Transcriptional cycling of activated glucocorticoid receptor (GR) and ultradian glucocorticoid secretion are well established processes. Ultradian hormone release is now shown to result in pulsatile gene transcription through dynamic exchange of GR with the target-gene promoter and GR cycling through the chaperone machinery.

Publication types

  • Comment
  • News

MeSH terms

  • Adrenal Cortex Hormones / blood
  • Adrenal Cortex Hormones / pharmacology*
  • Animals
  • Gene Expression Regulation / drug effects*
  • Humans
  • Mice
  • Models, Biological
  • Rats
  • Receptors, Glucocorticoid / metabolism
  • Response Elements / genetics
  • Transcription, Genetic / drug effects

Substances

  • Adrenal Cortex Hormones
  • Receptors, Glucocorticoid