Abstract
Transcriptional cycling of activated glucocorticoid receptor (GR) and ultradian glucocorticoid secretion are well established processes. Ultradian hormone release is now shown to result in pulsatile gene transcription through dynamic exchange of GR with the target-gene promoter and GR cycling through the chaperone machinery.
MeSH terms
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Adrenal Cortex Hormones / blood
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Adrenal Cortex Hormones / pharmacology*
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Animals
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Gene Expression Regulation / drug effects*
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Humans
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Mice
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Models, Biological
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Rats
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Receptors, Glucocorticoid / metabolism
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Response Elements / genetics
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Transcription, Genetic / drug effects
Substances
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Adrenal Cortex Hormones
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Receptors, Glucocorticoid