Therapeutic failure in a renal transplant patient with Pneumocystis jiroveci pneumonia: a case report

Exp Clin Transplant. 2009 Jun;7(2):129-32.

Abstract

Objectives: Pneumocystis jiroveci pneumonia is common in immunocompromised individuals.

Patients: This case report describes an immunosuppressed patient who acquired P jiroveci pneumonia 6 months after renal transplant surgery.

Results: The patient experienced many pneumonia-related complications and adverse effects from drug therapy, and despite treatment with various antibiotic agents, he died on the 62nd day after his admission to the intensive care unit.

Conclusions: The therapeutic failure of the drug of choice (co-trimoxazole) was evident. This case raises questions about the development of P jiroveci resistance to current therapies.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Infective Agents / therapeutic use*
  • Fatal Outcome
  • Humans
  • Immunocompromised Host*
  • Kidney Transplantation / immunology*
  • Male
  • Pneumocystis carinii / pathogenicity*
  • Pneumonia, Pneumocystis / drug therapy*
  • Pneumonia, Pneumocystis / immunology
  • Treatment Failure
  • Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use*

Substances

  • Anti-Infective Agents
  • Trimethoprim, Sulfamethoxazole Drug Combination