Population structure dynamics of Mycobacterium tuberculosis Beijing strains during past decades in Japan

Tomotada Iwamoto; Riyo Fujiyama; Shiomi Yoshida; Takayuki Wada; Chika Shirai; Yasuto Kawakami

doi:10.1128/JCM.01061-09

Population structure dynamics of Mycobacterium tuberculosis Beijing strains during past decades in Japan

J Clin Microbiol. 2009 Oct;47(10):3340-3. doi: 10.1128/JCM.01061-09. Epub 2009 Aug 26.

Authors

Tomotada Iwamoto¹, Riyo Fujiyama, Shiomi Yoshida, Takayuki Wada, Chika Shirai, Yasuto Kawakami

Affiliation

¹ Department of Microbiology, Kobe Institute of Health, Kobe, Japan. kx2t-iwmt@asahi-net.or.jp

Abstract

We used 909 strains to compare the population structures of the Mycobacterium tuberculosis Beijing family between different birth-year cohorts in Japan. The results revealed that the spread of a modern sublineage that has high transmissibility is currently increasing, while the spread of an ancient sublineage, STK, has significantly decreased in younger generations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Bacterial Typing Techniques
Female
Genotype
Humans
Japan / epidemiology
Male
Middle Aged
Molecular Epidemiology
Mycobacterium tuberculosis / classification*
Mycobacterium tuberculosis / genetics
Mycobacterium tuberculosis / isolation & purification*
Tuberculosis / epidemiology*
Tuberculosis / microbiology*
Tuberculosis / transmission