Trigochilides A and B, two highly modified daphnane-type diterpenoids from Trigonostemon chinensis

Org Lett. 2009 Sep 17;11(18):4080-3. doi: 10.1021/ol901506x.

Abstract

Trigochilides A (1) and B (2), two highly modified daphnane-type diterpenoids with 12-carbon-containing polyketide appendages at C-16 forming a macro-lactone with C-3, were isolated from the twigs and leaves of Trigonostemon chinensis. Their structures were elucidated by spectroscopic analysis. Trigochilides A (1) showed modest cytotoxicity against two tumor cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Diterpenes / classification
  • Diterpenes / therapeutic use*
  • Drug Screening Assays, Antitumor*
  • Drugs, Chinese Herbal / chemistry
  • Euphorbiaceae / chemistry*
  • HeLa Cells
  • Humans
  • K562 Cells
  • Lactones / pharmacology
  • Plant Leaves / chemistry
  • Structure-Activity Relationship
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Diterpenes
  • Drugs, Chinese Herbal
  • Lactones