Synthesis and in vivo diuretic activity of biphenyl benzothiazole-2-carboxamide derivatives

Acta Pol Pharm. 2009 Jul-Aug;66(4):387-92.

Abstract

A series of N-{(substituted)1,3-benzothiazol-2-yl}-1,1 '-biphenyl-4-carboxamides was synthesized by reaction between biphenyl acid chloride and 2-aminobenzothiazole. The synthesized compounds were screened in vivo for diuretic activity. Among the series, N-(1,3-benzothiazol-2-yl)-1,1'-biphenyl-4-carboxamide (II) was found to be the most promising candidate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzothiazoles / chemical synthesis*
  • Benzothiazoles / pharmacology
  • Diuretics / chemical synthesis*
  • Diuretics / pharmacology
  • Rats
  • Structure-Activity Relationship

Substances

  • Benzothiazoles
  • Diuretics