Two 22S-solanidine-type steroidal alkaloids from Fritillaria anhuiensis

Fitoterapia. 2010 Mar;81(2):81-4. doi: 10.1016/j.fitote.2009.08.017. Epub 2009 Aug 18.

Abstract

Phytochemical investigation of the fresh bulbs of Fritillaria anhuiensis S. C. Chen et S. E. Yin, resulted in the isolation of a known steroidal alkaloid solanidine of (22S,25S)-solanid-5-en-3beta-ol (1), which has never yet been found as a natural substance, and of a new steroidal alkaloid (22S,25S)-solanid-5,20(21)-dien-3beta-ol. Compounds 1 and 2 were the first solanidine-type alkaloids with 22-S configuration discovered from nature. Their structures were elucidated based on spectroscopic analysis, including 1D and 2D NMR experiments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diosgenin / analogs & derivatives*
  • Diosgenin / chemistry
  • Diosgenin / isolation & purification
  • Fritillaria / chemistry*
  • Molecular Structure
  • Plant Extracts / chemistry*
  • Plant Roots

Substances

  • (22S,25S)-solanid-5,20(21)-dien-3beta-ol
  • (22S,25S)-solanid-5-en-3beta-ol
  • Plant Extracts
  • Diosgenin
  • solanidine