Occurrence of OXA-107 and ISAba1 in carbapenem-resistant isolates of Acinetobacter baumannii from Croatia

J Clin Microbiol. 2009 Oct;47(10):3348-9. doi: 10.1128/JCM.02394-08. Epub 2009 Aug 19.

Abstract

Carbapenem-resistant isolates of Acinetobacter baumannii from intensive care units at Split University Hospital, Split, Croatia, were studied. Most (100 of 106) had ISAba1 inserted upstream of a bla(OXA-107) gene, encoding an unusual OXA-51-type oxacillinase. Pulsed-field gel electrophoresis revealed that the isolates formed three clusters belonging to the sequence group 2 (European clone 1) lineage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter Infections / microbiology*
  • Acinetobacter baumannii / classification
  • Acinetobacter baumannii / drug effects*
  • Acinetobacter baumannii / enzymology*
  • Acinetobacter baumannii / isolation & purification
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Typing Techniques
  • Carbapenems / pharmacology*
  • Child
  • Child, Preschool
  • Cluster Analysis
  • Croatia
  • Electrophoresis, Gel, Pulsed-Field
  • Female
  • Genotype
  • Humans
  • Infant
  • Infant, Newborn
  • Intensive Care Units
  • Male
  • Middle Aged
  • Molecular Epidemiology
  • Molecular Sequence Data
  • Young Adult
  • beta-Lactam Resistance*
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • beta-Lactamases

Associated data

  • GENBANK/EF650033