Abstract
Two new phenolic glycosides (1, 2), along with fourteen known compounds (3-16) have been isolated from the fruit of Cupressus sempervirens. The structures of these compounds were determined by spectroscopic analysis and were evaluated for their inhibitory activity against glycogen phosphorylase and glucose-6-phosphatase enzymes. Compounds 14 showed a moderate inhibition against glucose-6-phosphatase and 15 against glycogen phosphorylase enzymes.
Copyright (c) 2009 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Abietanes / chemistry
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Abietanes / isolation & purification*
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Abietanes / pharmacology
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Cupressus / chemistry*
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology
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Fruit
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Glucose-6-Phosphatase / antagonists & inhibitors*
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Glycogen Phosphorylase / antagonists & inhibitors*
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Glycosides / isolation & purification
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Glycosides / pharmacology
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Molecular Structure
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Phenols / isolation & purification
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Phenols / pharmacology
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Plant Extracts / chemistry*
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Plant Extracts / pharmacology
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Plant Leaves
Substances
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15-acetoxyimbricatolic acid
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Abietanes
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Diterpenes
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Enzyme Inhibitors
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Glycosides
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Phenols
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Plant Extracts
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ferruginol
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Glycogen Phosphorylase
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Glucose-6-Phosphatase